Colorectal Signet Ring Cell Carcinoma: Incidence and Epidemiological Distribution at a Tertiary Care Center from 2002 to 2012

Background: Primary colorectal signet ring cell carcinoma (SRCC) is a rare finding with an incidence of 0.9% to 4%. This entity is characterized by an aggressive tumor biological behavior and is associated with a worse outcome compared to mucinous or adenocarcinoma. SRCC are defined as carcinoma cells with ≥50% intracellular mucin of the tumor mass displacing the nuclei to the side. Tumor cells comprising ≥50% extracellular mucin of the tumor mass are classified as mucinous carcinomas. The aim of this study was to analyze the incidence and epidemiological distribution of SRCC in colorectal cancer patients at our…