Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc- mediated downregulation of cFLIP
A Bangert, S Cristofanon, I Eckhardt, B Ahangarian Abhari, S Kolodziej, S Häcker, S Hari Krishna Vellanki, J Lausen, KM Debatin, S Fulda · Klinische Pädiatrie · 2012 · Heft 11
Bibliografische Angaben
Zusammenfassung
Glioblastoma is the most common primary brain tumor with a very poor prognosis, calling for novel treatment strategies. Here, we provide first evidence that histone deacetylase inhibitors (HDACI) prime glioblastoma cells for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -induced apoptosis at least in part by c-myc-mediated downregulation of cellular FLICE-inhibitory protein (cFLIP). Pretreatment with distinct HDACI (MS275, suberoylanilide hydroxamic acid, valproic acid) significantly enhances TRAIL-induced apoptosis in several glioblastoma cell lines. Monitoring a panel of apoptosis-regulatory…
