Photodynamic treatment with Tetrahydroporphyrin Tetratosylat induces programmed cell death in human glioblastoma cell lines

Prognosis of patients with malignant gliomas such as glioblastoma multiforme (GBM) remains extremely bad. Current treatment options result in a median survival of about 14 month demanding new strategies. Photodynamic therapy has found so far only very limited application in tumor therapy mainly due to the poor therapeutic depth reached. The recently developed photosensitzer Tetrahydroporphyrin Tetratosylat (THPTS) might overcome this draw back by its long wavelength activation (760nm) and high absorption coefficient. In this study we aim to investigate therefore, if photodynamic treatment using THPTS combined wi…