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Thyroid dysfunction induced by peginterferon alfa-2b (Peg-2b)/Ribavirin (RBV) is a favorable predictor of SVR in difficult-to-treat patients with HCV Genotype 1 (G1) infection

S Mauss, D Hueppe, E Zehnter, MP Manns, G Teuber, T Dahhan, U Meyer, T Witthoeft, B Moeller, N Dikopoulos, J Brack, D Hartmann, M Bilzer · Zeitschrift für Gastroenterologie · 2012 · Heft 08

Dokument
868335
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
S Mauss, D Hueppe, E Zehnter, MP Manns, G Teuber, T Dahhan, U Meyer, T Witthoeft, B Moeller, N Dikopoulos, J Brack, D Hartmann, M Bilzer
Ausgabe
Heft 08 / 2012
Seiten
–
Erschienen: 2012-08-22 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0032-1324001

Zusammenfassung

Aims: Thyroiditis leading to thyroid dysfunction in up to 15% of pts treated for chronic HCV infection has been attributed to interferon-stimulated immune mechanisms similar to that in antiviral response induced by interferons. We analyzed the possible association between thyroid dysfunction related to Peg2b/RBV and the virologic outcome of pts treated for HCV G1 infection. Methods: Data from 1923 pts treated for G1 infection with Peg2b 1.5µg/kg/wk+weight-based RBV 800–1200mg/day for up to 48 wks in an observational real-life study at 285 sites in Germany were retrospectively analyzed. Thyroid dysfunction was es…

Schlagworte

Zeitschrift für Gastroenterologie