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A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1

A Fischer, B Schmid, D Ellinghaus, M Nothnagel, KI Gaede, M Schürmann, S Lipinski, P Rosenstiel, G Zissel, K Höhne, M Petrek, V Kolek, S Pabst, C Grohé, J Grunewald, M Ronninger, A Eklund, L Padyukov, C Gieger, E Wichmann, A Nebel, A Franke, J Müller-Quernhei… · Pneumologie · 2012 · Heft 11

Dokument
868523
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
A Fischer, B Schmid, D Ellinghaus, M Nothnagel, KI Gaede, M Schürmann, S Lipinski, P Rosenstiel, G Zissel, K Höhne, M Petrek, V Kolek, S Pabst, C Grohé, J Grunewald, M Ronninger, A Eklund, L Padyukov, C Gieger, E Wichmann, A Nebel, A Franke, J Müller-Quernhei…
Ausgabe
Heft 11 / 2012
Seiten
–
Erschienen: 2012-11-13 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1329831

Zusammenfassung

Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Amongst others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. In order to identify additional risk loci for sarcoidosis and its acute and chronic subforms, we analyzed imputed data from a genome-wide association scan (GWAS) for these phenotypes. After quality control, the GWAS comprised nearly 1.3 million imputed single nucleotide polymorphisms based on an Affymetrix 6.0 Gene Chip dataset of 564 German sarcoidosis cases, including 176 acute and 354 chronic cases and…

Schlagworte

Pneumologie