Textural features in FDG-PET/CT can predict outcome in melanoma patients to treatment with Vemurafenib and Ipililumab
Daniela Dittrich, Thomas Pyka, Klemens Scheidhauer, Susanne Lütje, Markus Essler, Ralph A. Bundschuh · Nuklearmedizin - NuclearMedicine · 2020 · Heft 03 · S. 228-234
Bibliografische Angaben
Zusammenfassung
Abstract Aim Recently, textural parameters assessed in FDG-PET/CT as surrogate marker for tumor heterogeneity have been shown to provide prognostic power. Therefore, we investigated the use of such parameters in FDG-PET/CT examinations before the start of immunotherapy with vemurafenib or ipilimumab in patients with malignant melanoma. Methods In this retrospective analysis 26 patients with histologically proven advanced melanoma were included. FGD-PET/CT was performed before the start of treatment either with vemurafenib (n = 9) or ipilimumab (n = 17) and tumors were analyzed for textural parameters as well as…
