DNA methylation signatures in non-alcoholic fatty liver disease reveal disease-specific signatures and molecular remodelling drivers after weight loss in non-alcoholic fatty liver…
M Ahrens, O Ammerpohl, W von Schönfels, T Itzel, A Teufel, M Brosch, J Egberts, B Sipos, S Schreiber, F Stickel, T Becker, C Röcken, R Siebert, C Schafmayer, J Hampe · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Epigenetic regulation is a key element in the determination of cellular faith and function and plays an important role in the pathogenesis of both malignant and benign disorders. Methods: In order to define the as yet largely unexplored epigenetic signature of NALFD, DNA methylation in liver samples of normal controls (NC, N=18) and morbidly obese patients with normal liver histology (HO, N=19), steatosis (ST, N=12) and NASH (NA, N=15) as determined by the NAS histology score was analysed…
