Metabolomic tissue signature in human non-alcoholic fatty liver disease identifies protective candidate metabolites
W von Schönfels, E Patsenker, M Ahrens, R Fahrner, H Hinrichsen, O von Kampen, M Brosch, A Gruodyte, J Egberts, A Arlt, K Richter, A Landrock, B Sipos, K Balschun, S Schreiber, M Krawczyk, G Beldi, T Becker, C Röcken, F Stickel, C Schafmayer, J Hampe · Zeitschrift für Gastroenterologie · 2013 · Heft 01
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Zusammenfassung
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder in developed countries in the context of the global obesity epidemic. A two-stage metabolic screening of human liver biopsies (discovery set: N=33; replication set: N=66) including the range from normal liver histology to severe non-alcoholic steatohepatitis (NASH) analysed the correlation of 252 metabolites to the histological NASH activity score. Six metabolites passed correction for multiple testing in the discovery set and two of those, namely hydroquinone (HQ, pcombined=3.0×10–4) and nicotinic acid (NA, pcombined=3.9…
