Distinct Roles for Chk2/p53/p21 pathway in Liver Injury and Hepatocarcinogenesis
LE Buitrago-Molina, S Marhenke, T Longerich, AE Boukouris, R Geffers, B Guigas, MP Manns, A Vogel · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and aims: Hepatocellular carcinoma (HCC) frequently arises in the context of chronic injury promoting DNA damage and chromosomal aberrations. Our aim was to further de-lineate the role of Chk2, p53 and p21 during acute and chronic liver injury and HCC initiation and progression. Methods: Mice with a targeted genetic deletion of Chk2, p53 or p21 were crossed into a murine model of human disease hereditary tyrosinemia type-1 (HT1). HT1 is characterized by an extremely high susceptibility for hepatocarcinogenesis. Results: Deletion of Chk2 does not affect tumor initiation in the liver, but significantly…
