Are metabolomic markers associated with spirometric lung function indices? Results of the KORAF4 Study
C Flexeder, S Karrasch, G Kastenmüller, C Meisinger, AP Petersen, C Prehn, R Wang-Sattler, S Weidinger, C Gieger, J Heinrich, R Holle, A Peters, T Illig, J Adamski, K Suhre, H Schulz · Pneumologie · 2013 · Heft 02
Bibliografische Angaben
Zusammenfassung
Aims: Respiratory function shows a large interindividual variability which is related to genetic, developmental and environmental factors. These determinants influence the individual's metabolism, but little is known about metabolic processes and lung function. Therefore, this study investigates the association between lung function indices and concentrations of metabolomic markers in adults from a population-based study. Methods: Spirometry was performed in a subpopulation of the KORA-F4 cohort (Augsburg, Germany) comprising 1312 subjects aged 41 to 62 years. In fasting blood samples over 650 metabolites were d…
