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Global methylation level in human adipose tissue is related to fat distribution

M Keller, D Schleinitz, I Müller, M Stumvoll, P Kovacs, M Blüher, Y Böttcher · Diabetologie und Stoffwechsel · 2013 · Heft 04

Dokument
870403
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
M Keller, D Schleinitz, I Müller, M Stumvoll, P Kovacs, M Blüher, Y Böttcher
Ausgabe
Heft 04 / 2013
Seiten
–
Erschienen: 2013-04-19 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0033-1341831

Zusammenfassung

Aims: Epigenetic mechanisms may influence metabolic processes involved in human obesity. We examined the global methylation level in human subcutaneous vs. visceral adipose tissue and its relationship to obesity and related phenotypes. Methods: We measured global methylation level using LUMA in paired samples of subcutaneous and visceral adipose tissue from 51 Caucasian individuals. Further, we analyzed the correlation of global DNA methylation in adipose tissue with parameters of obesity (BMI, WHR and fat area), glucose metabolism and insulin sensitivity. Results: Global methylation levels were significantly hi…

Schlagworte

Diabetologie und Stoffwechsel