High-field MR-Spectroscopy (MRS) allows novel insights in alterd hepatic lipid and energy metabolism in NAFLD with potential distinction of NASH and advanced fibrosis
S Traussnigg, E Halilbasic, C Kienbacher, M Gajdosik, L Valkovic, M Chmelik, J Stift, H Hofer, P Munda, P Ferenci, A Ba-Ssalamah, F Wrba, S Trattnig, M Krssak, M Trauner · Zeitschrift für Gastroenterologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background/Aims: The rising prevalence of NAFLD and the imperfect gold standard of liver biopsy calls for better diagnostic methods. We aimed to evaluate MRS as non-invasive tool also permitting novel mechanistic and pathogenetic insights into alterations of hepatocellular metabolism in NAFLD. We therefore quantified hepatocellular lipid content (HCL) by 3.0-T 1 H-MRS and 31P-metabolites by 7.0-T 31P-MRS to assess whether MRS permits a non-invasive distinction between NAFL, NASH and different fibrosis stages. Methods: MRS was obtained immediately before liver biopsy in suspected NAFLD and data were correlated wi…
