Neuroimmunomodulation in the oral mucosa of the diabetic rat

Background: Increasing evidence indicates that different neuropeptide-containing nerve elements are involved in the immune system and influence the inflammation of the gastrointestinal tract. The aim was to investigate the morphological localization and distribution of the different immunoreactive nerve fibers and immunocompetent cells in the oral mucosa (e.g. tongue and gingiva) and compare with the data received from streptozotocin induced diabetic rats. Materials and methods: The different nerve elements and immunocytes were detected by ABC immunohistochemistry. Results: The immunoreactive (IR) nerve fibres w…