Detection and clinical relevance of hematogenous tumor cell dissemination in patients with ductal carcinoma in situ
M Banys, I Gruber, S Becker, N Krawczyk, R Kurth, A Hartkopf, D Wallwiener, A Staebler, T Fehm · Senologie - Zeitschrift für Mammadiagnostik und -therapie · 2013 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background: Hematogenous tumor cell dissemination is considered a crucial step in systemic disease progression. Only invasive cancers are assumed to shed tumor cells into the bloodstream. However, disseminated tumor cells (DTCs) may be detected in the bone marrow of patients with preinvasive lesions. The purpose of this analysis was to examine the incidence and clinical value of DTC detection in DCIS patients. Methods: 404 DCIS patients were included into this analysis. BM was analyzed by immunocytochemistry (A45-B/B3). Sentinel nodes were analyzed in 283 of these patients by extensive step sectioning and hemato…
