The magnitude of pulmonary inflammation induced by Carbon Black nanoparticles is connected to the internal circadian rhythm of the lung

Throughout the daily rhythm, the lung shows physiological and functional changes. Disruption of the circadian rhythm is associated with alterations in the immune system and its dysfunction as seen in chronic lung diseases such as asthma and COPD. The circadian rhythm, being a 24-hour period, is regulated by the central clock in the brain. However, circadian timers (Zeitgeber) are also found in peripheral tissues such as the lung. Physiological changes of peripheral organs due to a malfunction in its circadian rhythm may be an important factor of pre-disposition causing significant differences in the response to…