MicroRNAs as Mediators in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Steatohepatitis
PP Becker, B Niesler, O Tschopp, F Berr, A Canbay, T Dandekar, B Müllhaupt, J Schmitt, A Geier · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Objectives: The biological mechanisms of non-alcoholic fatty liver disease (NALFD) and non-alcoholic steatohepatitis (NASH) are not entirely understood particularly in human liver. Since microRNAs (miRNAs) have been discovered, scientists proofed a regulative function in various gene expression pathways. Aim of this project is to study miRNAs expression and related target gene mRNA expression patterns in different stages of human fatty liver disease. Methods: In an initial miRNA expression assay total RNA from liver tissue of 19 patients with NAFLD/NASH from the local biobank and five healthy controls was analyz…
