A p19(Arf) and Aurka mediated G2/M arrest restricts oncogenic transformation of p53 deficient hepatocytes
D Dauch, T Wuestefeld, TW Kang, R Rudalska, JC Nault, A Hohmeyer, L Hoenicke, P Schirmacher, T Longerich, J Zucman-Rossi, L Zender · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
The tumor suppressor protein p19Arf (p14 in human) induces activation of p53 upon oncogenic stress. However, other functions of p19Arf, which are independent of p53 are also under discussion. To identify new tumor suppressive networks of p19Arf in hepatocellular carcinoma (HCC), we established a new mosaic liver cancer mouse model, based on the delivery of oncogenes and marker genes in combination with shRNAmir induced gene knockdown into murine hepatocytes via transposable elements. The analysis of NrasG12V triggered liver cancer identified striking differences of tumor onset in different genetic backgrounds. W…
