NK cell activity promotes liver damage and chronic viral infection
PA Lang, HC Xu, M Grusdat, I Parish, M Recher, A Elford, S Dhanji, N Shaabani, CW Tran, D Dissanayake, R Rahbar, M Ghazarian, A Brustle, J Fine, P Chen, CT Weaver, C Klose, A Diefenbach, JR Carlyle, SM Kaech, TW Mak, PS Ohashi, D Häussinger, KS Lang · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Infections with hepatitis B virus and hepatitis C virus can turn into chronic infections, which currently affect more than millions of patients worldwide. Virus mediated T cell exhaustion results in limited T cell function thus promoting chronic virus infection and disease. Here we demonstrate that NK cells have a negative impact on the development of T cell immunity using the murine lymphocytic choriomeningitis virus (LCMV). NK cell deficient (nfil3-/-, E4BP4-/-) mice exhibited a higher virus specific T cell response. Accordingly, NK cell depletion caused enhanced viral induced hepatitis in WT mice when compare…
