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Safety of add on Interferon-alpha-2a in hepatitis B patients receiving effective nucleos(t)de therapy: Interim results from the German multicenter PADD-ON trial

MF Sprinzl, A Grambihler, A Ehrlich, J Kittner, M Ebert, S Zeuzem, M Cornberg, J Lohmeyer, F Tacke, C Eisenbach, F Geisler, U Spengler, E Schott, PR Galle · Zeitschrift für Gastroenterologie · 2014 · Heft 01

Dokument
872553
CareLit-ID
Jahr
2014
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
MF Sprinzl, A Grambihler, A Ehrlich, J Kittner, M Ebert, S Zeuzem, M Cornberg, J Lohmeyer, F Tacke, C Eisenbach, F Geisler, U Spengler, E Schott, PR Galle
Ausgabe
Heft 01 / 2014
Seiten
–
Erschienen: 2014-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0033-1361051

Zusammenfassung

Background: Treatment of chronic hepatitis B (cHB) with nucleos(t)ide analogues or Interferon-alpha (IFN) monotherapy regularely fails persistent immune control and HBsAg elimination. Hence, we initiated a prospective multicenter trial (PADD-ON) to investigate the addition of IFN to an ongoing nucleos(t)ide treatment. Here we report the study protocol and interim safety data obtained during ongoing study recruitment. Methods: HBeAg negative cHB patients (HBsAg > 100 IU/ml) showing stable HBV suppression (HBV-DNA < 20 IU/ml) for > 1 year under nucleos(t)ide analogue administration are randomized (2:1) to receive…

Schlagworte

Zeitschrift für Gastroenterologie