Regulation of macroautophagy in amiodarone induced pulmonary fibrosis
P Mahavadi, I Henneke, L Knudsen, C Ruppert, S Venkatesan, G Liebisch, RC Chambers, K Piskulak, M Ochs, G Schmitz, C Vancheri, W Seeger, M Korfei, A Guenther · Pneumologie · 2014 · Heft 02
Bibliografische Angaben
Zusammenfassung
Rationale: Amiodarone (AD) is a well known anti arrhythmic drug, limited by its potential side effects. Severe pulmonary toxicity is reported in patients receiving amiodarone even at low doses, most common histological finding being chronic interstitial pneumonia. Amiodarone is known to induce autophagy in some cell types. A potential role for autophagy in the development of lung fibrosis has not been elucidated so far. Aims: We aimed to establish a murine model of amiodarone induced pulmonary fibrosis and assess the role of autophagy. Methods: AD or vehicle was instilled intra tracheally into C57BL/6 mice, and…
