Connectivity as a marker for accurate diagnosis in Disorders of Consciousness (DOC)

Question: Recent studies revealed differences in signal distribution inDOC-patients, depending on the diagnosis. We investigated systematic differences in transcallosal coherence. Greater coherence in healthy than in DOC-Patients and greater coherence in patients in a minimally conscious state (MCS) than patients with unresponsible wakefulness syndrome (UWS) was expected. Methods: Rest-EEG was recorded in 66 subjects (24 MCS, 30 UWS, 12 Healthy). The absolute value of coherence between each electrode of the left hemisphere and each electrode of the right hemisphere was computed (F3, F4, C7, F8, C3, C4, P3, P4, O…