CareLit Fachartikel

Concurrent deIetions of IKZF1 and PAX5, CDKN2A, CDKN2B or PAR1 (IKZF1plus) confer a very poor prognosis in pediatric acute lymphoblastic leukemia

E Dagdan, M Zaliova, M Zimmermann, P Dörge, A Möricke, A Teigler-Schlegel, R Koehler, CR Bartram, J Alten, D Schewe, C Kratz, RS Houlston, M Schrappe, G Cario, M Stanulla · Klinische Pädiatrie · 2014 · Heft 05

Dokument
873227
CareLit-ID
Jahr
2014
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
E Dagdan, M Zaliova, M Zimmermann, P Dörge, A Möricke, A Teigler-Schlegel, R Koehler, CR Bartram, J Alten, D Schewe, C Kratz, RS Houlston, M Schrappe, G Cario, M Stanulla
Ausgabe
Heft 05 / 2014
Seiten
–
Erschienen: 2014-05-12 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0034-1374831

Zusammenfassung

Recently, we described GATA3 (rs3824662) as a new susceptibility locus for pediatric acute lymphoblastic leukemia (ALL; Blood;122:3298 – 3307). The variant GATA3 allele was specifically associated with so-called B-other ALL and conferred a dismal outcome. Here, we analyzed in 500 patients treated on trial AIEOP-BFM 2000 which somatic genetic aberrations describe the group of B-other ALLs associated with rs3824662 to identify the leukemia genetics underlying the prognostic effect of GATA3 germline genetic variation. GATA3 rs3824662 genotype was negatively associated with hyperdiploidy and positively associated wi…

Schlagworte

Blood Allele Klinische Pädiatrie