CD57high neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patients
AM Schlitter, C Dorneburg, TFE Barth, J Wahl, JH Schulte, S Brüderlein, KM Debatin, C Beltinger · Klinische Pädiatrie · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Neuroblastoma is thought to originate from neural crest-derived cells. CD57 defines migratory neural crest cells in normal development and is expressed in neuroblastoma. Methods: We investigated the role of CD57 expression in neuroblastoma cells ex situ and in situ. Results: Compared to CD57low U-NB1 neuroblastoma cells, CD57high cells developed tumors with decreased latency after orthotopic transplantation into adrenal glands of mice. In addition, CD57high U-NB1 and SK-N-BE(2)-C neuroblastoma cells were also more clonogenic, induced more spheres and were less lineage-restricted. CD57high cells att…
