Long-term effects of chronic variable stress on insulin sensitivity
S Müller-Lühlhoff, T Jelenik, S Hartwig, S Lehr, P Nowotny, M Roden, H Al-Hasani, TR Castañeda · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aim: Stress is a state of threat to homeostasis and increases the incidence of type-2 diabetes. However, the long-term effects of chronic stress on insulin sensitivity are yet unknown. We aimed to characterize how chronic variable stress (CVS) affects insulin sensitivity on the long-term in mice. Methods: Age- and body weight (BW)-matched male C57BL/6 mice were exposed to a random series of stressors for 15 days (CVS, n = 12), controls were housed separately (Ctrl, n = 12). Body composition was analyzed by NMR. Plasma corticosterone was analyzed with RIA. Three months after CVS insulin sensitivity was analyzed i…
