Effects of liraglutide in an adolescent prediabetic transgenic pig model

Aim: To evaluate the effect of the glucagon-like peptide-1 analogue liraglutide on glycemic control, body weight, food intake, alpha- and beta-cell mass in adolescent transgenic pigs expressing a dominant-negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn) (Renner et al., Diabetes 59:1228 – 1238, 2010). Methods: GIPRdn transgenic pigs were treated with 0.6 mg – 1.8 mg liraglutide or placebo subcutaneously once daily for 90 days. Glucose tolerance was evaluated in a mixed meal oral test. Finally animals were subjected to necropsy and alpha- as well as beta-cell mass were determined by quantita…