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Analysis of novel obesity genes with the aid of congenic rats

A Maak, I Klöting, M Stumvoll, N Klöting · Diabetologie und Stoffwechsel · 2014 · Heft 05

Dokument
873247
CareLit-ID
Jahr
2014
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
A Maak, I Klöting, M Stumvoll, N Klöting
Ausgabe
Heft 05 / 2014
Seiten
–
Erschienen: 2014-05-06 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0034-1375031

Zusammenfassung

Background: Studies in rats have revealed a link between a number of quantitative trait loci (QTLs) with facets of the metabolic syndrome. A QTL for serum cholesterol and body weight was identified on rat chromosome 10. Methods: We generated a congenic rat strain, DA.WOKW10 and new sub-congenic rat strains for rat chromosome 10. Phenotyping and genotyping comparison of sub-congenic rat lines compared to parental strains have been performed. Phenotyping includes body weight gain up to an age of 30 weeks. Per strain and gender 10 rats have been studied. At the end of observation period we analyzed serum levels of…

Schlagworte

Adiponectin Cholesterol Observation C-Peptide After Obesity Diabetologie und Stoffwechsel