Apelin play an important role in angiogenesis of mouse retina
L Chen, J Lin, J Wang, M Aras, M Kolibabka, N Dietrich, L Kern, YR Jiang, HP Hammes · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aim: Apelin is upregulated in the vitreous of patients with diabetic retinopathy. Apelin and its receptor APJ are primarily expressed in endothelial cells contributing to angiogenesis. Apelin stimulates the proliferation of retinal cells in vitro. However, whether apelin is involved in the regulation of retinal vascularization remains unknown. Methods: Quantitative RT-PCR was used to assess apelin expression on postnatal day 5 (p5) to 17 (p17) in C57Bl/6 mice. Recombinant apelin-13 was injected intraperitoneally at p4/p5/p6 or p7/p8/p9. The vasculature of the superficial and the deep capillary layer were analyze…
