Comparison of MII-PH-metry data in patients with functional heartburn and proton pump inhibitor treatment responsive non-erosive reflux disease

Patients with non-erosive reflux disease (NERD) may or may not respond to a proton pump inhibitor (PPI). Refractoriness can be non-reflux or reflux related. In the absence of structural, motility or inflammatory causes, functional heartburn (FH) should be considered. Patients with FH have typical reflux symptoms with lack of association with reflux episodes on multichannel intraluminal impedance pH- monitoring (MII-pH-metry) and do not respond to double dose PPI therapy. Recent study demonstrated an increased acid sensitivity in patients with NERD compared with that in patients with FH. The aim of our study was…