Simulation of physiologic conditions in diseased lung grafts for drug exposition using the Organ Care System – a new model

The only curative treatment option for patients with end-stage lung disease is lung transplantation, since no curative pharmacological drug for diseases is known so far. In order to analyze the effect of new drugs on diseased tissue and vasculature, we developed an ex vivo lung perfusion (EVLP) setup, in which explanted diseased lungs from lung transplant recipients cab be treated with new drugs whilst undergoing normothermic perfusion and ventilation. Here, we present data from our first three lungs, that were put on EVLP in order to proof the feasibility of the experimental setup. Methods: For EVLP, the Organ…