The role of miR-34a as a prognostic biomarker for cirrhotic patients with portal hypertension receiving TIPS
C Jansen, H Eischeid, J Goertzen, R Schierwagen, E Anadol, CP Strassburg, T Sauerbruch, M Odenthal, J Trebicka · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Circulating miR-34a is increased in blood of patients with different liver diseases when compared to healthy controls. However, the origin of miR-34a and its possible relationship with hemodynamics and outcome in cirrhotic patients with portal hypertension is unknown. We analyzed the levels of miR-34a in the portal and hepatic vein of cirrhotic patients with severe portal hypertension. Methods: We included 60 cirrhotic patients receiving TIPS for prevention of rebleeding and/or therapy-refractory ascites. miR-34a levels were measured using qPCR and normalized by spike-in SV-40 RNA in the portal and h…
