New insights in CapG induced invasive breast cancer – CapG affects gene expression

Objective: CapG expression is increased in about 30% of breast cancer samples and correlates with migration and invasion potential of tumor cells. Moreover nuclear localization of CapG seems to be important to increase the invasion potential. However the function of CapG in the nucleus is unclear and possible influences on gene expression are discussed. Therefore we performed CapG transcriptome analyses to augment the understanding of the mechanisms. Material and methods: CapG knock-down and overexpression was performed using siRNA and retroviral transfection, respectively. BioCoat™Matrigel™ was used for the inv…