Targeting class I histone deacetylases in high risk medulloblastoma – analysis of molecular mechanisms and translational implications

Introduction: Medulloblastoma (MB) is the most frequent pediatric malignant brain tumor. Four molecular subgroups with distinct genetic and epigenetic backgrounds as well as clinical characteristics have been identified. Especially in patients with Group 3 tumors overall survival remains poor despite aggressive multimodal treatment. We and others have previously shown that targeting MB tumors with histone deacetylase inhibitors (HDACis) is a promising strategy. The current study explores the molecular mechanisms and translational implications of class I HDAC inhibition in high risk Medulloblastoma subgroups. Met…