Irradiation of freeze-thaw lysate used to pulse dendritic cells further increases antitumor immunity in a mouse model of high-grade glioma

The prognosis of high-grade glioma is poor despite of advanced neurosurgery, radio-and chemotherapy. Dendritic cell (DC)-based immunotherapy has emerged as a promising and feasible treatment approach because of it's high degree of selectivity and the ability to induce a memory response. In our research group we are investigating the efficacy of vaccinating both primary (HGG-2006 trial) and relapsed HGG patients (HGG-IMMUNO-2003 trial) with DC pulsed with autologous whole tumor lysate. Both trials showed a better overall survival compared to historical controls. Currently we are running a placebo-controlled rando…