Damage of the non parenchymal cells after acetaminophen intoxication is critical for liver regeneration

Acetaminophen (APAP)is a safe antipyretic and pain relieving drug when used at normal therapeutic doses. However, overdoses of APAP are commonly associated with acute liver damage. Due to the vital functions of the liver, a rapid well-orchestrated regeneration is essential after injury, in contrast to the quiescent state of healthy liver. The aim of this study is to investigate the influence of APAP intoxication on various hepatic cells in mice and the impact of each individual cell type on liver regeneration. For this purpose male C57B6/n mice received a single low (200 mg/kg) or high (450 mg/kg) dose of APAP.…