IL-37 requires IL18Rα and SIGIRR to ameliorate experimental allergic asthma in mice

Rationale: Recently, the new cytokine interleukin (IL) 37 has been described as a negative regulator of the innate immune system. It reduces activation of DCs and the production of pro-inflammatory mediators in TLR stimulated murine and human macrophage, monocyte and epithelial cell lines. Results from the CLARA study gave the first hint towards an implication of IL-37 in asthma pathogenesis. However, until yet it is unknown, whether IL-37 plays a role in asthma pathogenesis by providing anti-inflammatory effects on an adaptive immune response and through which receptor it exerts such effects. Methods: Periphera…