IVA induced IFNs facilitate development of secondary pneumococcal pneumonia in human lung tissue
J Berg, K Hellwig, D Stoll, A Becher, T Wolff, M Tönnies, TT Bauer, P Schneider, J Neudecker, JC Rückert, O Kershaw, AD Gruber, N Suttorp, S Hippenstiel, AC Hocke · Pneumologie · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: Preceding influenza virus A (IVA) infections can predispose the lung to secondary bacterial pathogens like Streptococcus pneumoniae (S.p.) by modulation of the anti-bacterial defence, which is associated with higher morbidity and mortality. However, mechanisms underlying the inflammatory potentiating effect of IVA for S.p. infections in human lung tissue are still unclear. Besides morphological changes of the alveolar epithelium, resulting in improved access to receptors, the influence of IVA regarding changes of inflammatory immunity seems to be an important factor contributing to the severeness o…
