STZ treatment causes depletion of immune cells in sciatic nerve and dorsal root ganglion in mice

Introduction: Streptozotocin (STZ) treatment is an accepted pharmacological method for the induction of type 1 diabetes in rodent models. Recent publications have shown that STZ induces thermal hyperalgesia in mice, independently of hyperglycemia, and that STZ is neurotoxic in vitro. These findings bring into question the limitations of STZ-induced diabetes as a model for diabetic neuropathy. The aim of this study was to investigate effects of STZ treatment on nerve physiology in vivo. Methods: Healthy, wild-type mice were treated with STZ (50 mg/kg) i.p. Mice were sacrificed at different timepoints and the chan…