The role of the Golgi apparatus on adipocyte secretory function

Background/Aim: Circulating adiponectin, which has insulin sensitizing effects on liver and muscle, is synthesized at the endoplasmic reticulum and proceeds through compartments of the Golgi apparatus prior to its secretion into the bloodstream. We have recently observed that postnatal adipocyte-specific deletion of the trans-Golgi associated GTPase ARFRP1 (ADP-ribosylation factor-related Protein1), which is required for organizing specific protein scaffolds in this compartment, resulted in elevated blood glucose levels and increased hepatic glucose production in the absence of ectopic fat storage. We therefore…