CareLit Fachartikel

Metabolic flexibility, insulin sensitivity and genetic variations in newly diagnosed patients with type 2 diabetes

M Apostolopoulou, K Strassburger, B Knebel, J Kotzka, J Szendroedi, M Roden · Diabetologie und Stoffwechsel · 2015 · Heft 04

Dokument
877273
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
M Apostolopoulou, K Strassburger, B Knebel, J Kotzka, J Szendroedi, M Roden
Ausgabe
Heft 04 / 2015
Seiten
–
Erschienen: 2015-04-29 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0035-1549661

Zusammenfassung

Patients with type 2 diabetes (T2D) frequently show a lower increase in respiratory quotient (ΔRQ, metabolic flexibility) during hyperinsulinemia and lower maximal oxidative capacity (VO2max). Genes affecting insulin sensitivity such as peroxisome proliferator-activated receptor gamma (PPARG) and PPARG-coactivator-1 alpha (PGC1A) or response to exercise training such as PPAR delta (PPARD) and adrenergic receptor beta 2 (ADRB2) could contribute to differences in ΔRQ, VO2max or insulin resistance. Thus, we analyzed single nucleotide polymorphisms (SNPs) of these genes in a prospective multicenter study on new onse…

Schlagworte

Diabetologie und Stoffwechsel