Gene signature underlying β-cell compensation in metabolic distress

Research Question: Genetic factors play a decisive role in developing type 2 diabetes in obese patients as only a subset of people with risk factor such as obesity, insulin resistance and pregnancy develop type 2 diabetes. We aimed to identify overexpressed gene signature, underlying increased beta cell compensation in obesity Methodology: A 'cluster' of genes overexpressed in non diabetic C57BL/6J ob/ob mice (as compared to diabetic BTBR ob/ob mice) were selected, based on 'consensus' over expression status approach i.e., the shortlisted genes were significantly upregulated in C57BL/6J ob/ob mice as well as als…