The association between vitamin D and the arachidonate 5-lipoxygenase (ALOX-5) gene polymorphism in type 2 diabetes

Introduction: Arachidonate 5-lipoxygenase (ALOX-5) metabolizes arachidonic acid. The role of ALOX-5 in Type 2 Diabetes (T2D) is not known but a vitamin D (VD) regulation is postulated due to a VD response element (VDRE) upstream. The aim of this study was to investigate a single nucleotide polymorphism (SNP) rs4987105, located in a regulatory region of ALOX-5 nearby a VDRE, in T2D patients and in healthy controls (HC) as well as its interaction with the VD pathway. Methods: 533 German T2D patients and 473 HC were genotyped by Taqman assay. Further, the 25(OH)D3 and 1,25(OH)2D3 plasma levels were measured by radi…