Parathyroid hormone is related to dysplasia and a higher rate of distal colorectal adenoma in women

Background: Molecular and clinical observations provide evidence for a potential role of parathyroid hormone (PTH) in colorectal cancer development. No study has been performed to assess the association of PTH with regard to colorectal cancer precursor lesions. Material and Methods: One-thousand-four-hundred and thirty-two subjects (777 males, 58.4 ± 9.6yrs; 701 females, 59.1 ± 10.6yrs) were included. Men and women were allocated to PTH serum concentrations either above or below 55 ng/L. The number, localization, size and histology of the polypoid lesions detected during screening colonoscopy were recorded. Resu…