Usefulness of interferon Lambda-4, HLA Class II Polymorphysims and Killer-Immunglobuline-Like Recptor-2DL3:C1/C1 to predict spontaneous clearance of acute Hepatitis C virus infect…

Background & Aims: Spontaneous resolution of acute hepatitis C virus infection (AHC) largely depends on the patient's immuno-genetic background. Besides IL-28B (rs12979860), Interferon-Α4/rs469415590- and HLA-class-II/rs4273729 polymorphisms (PMs) as well as the detectability of killer-cell-immunoglobulin-like-receptor with it's ligands (KIR)2DL3:HLA-C1/C1 might influence spontaneous clearance (SC) of AHC. We aimed to investigate if these genetic factors predict SC in patients with acute HCV-infection. Patients & Methods: IL-28B/rs12979860-, IFNΑ4/rs469415590- and HLA-class-II/rs4273729 polymorphisms were determ…