Pulmonary IL-13 expression is increased by airway surface dehydration in vivo
S Christochowitz, C van Bodegom, S Schmidt, E Maier, M Hagner, J Fellenberg, MA Mall, B Fritzsching · Pneumologie · 2015 · Heft 07
Bibliografische Angaben
Zusammenfassung
Introduction: We have previously demonstrated that mice with airway specific overexpression of the epithelial Na+ channel (βENaC-Tg) exhibit airway surface dehydration and eosinophilic airway inflammation in juvenile mice (Mall MA, Am J Respir Crit Care Med 2008). We hypothesized that airway surface dehydration may increase the susceptibility for allergic airway inflammation and treatment with allergen could induce IL-13 expression in vivo. Here, we evaluated cellular sources of IL-13 expression in response to allergen treatment in wild-type and βENaC-Tg mice. Methods: Juvenile wild-type and βENaC-Tg mice were c…
