The Pregnancy Associated Endometrial Protein Glycodelin and its Potential as a Biomarker for Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with a short survival time arising from the mesothelial cells of the pleura. MPM is mainly associated with asbestos exposure and a strong inflammatory reaction. The common treatment of MPM combines macroscopic complete resection (MCR) and adjuvant or neoadjuvant chemotherapy, respectively. Soluble mesothelin and osteopontin are current available biomarker for malignant mesothelioma with moderate sensitivity and specificity. Here we demonstrate that glycodelin, an immune system modulator, well described during fertilization and implantation, migh…