Chemovirotherapy – Improving the clinical outcome of advanced pancreatic adenocarcinoma by combining the oncolytic vaccinia virus GLV-1h68 with the dual chemotherapy nab-Paclitaxe…

Background: Oncolytic viruses have proven their therapeutic potential against a variety of different tumor entities both in vitro and in vivo. Their ability to selectively infect and lyse tumor cells, while sparing healthy tissues, makes them a favorable agent in specific tumor treatment. The collected evidence suggests that only in combination with already established forms of treatment their true therapeutic potential can be unlocked, preferably in combination with chemotherapeutics (so called chemovirotherapy). Due to the fact that the mechanisms of action of these two distinct approaches differ greatly the c…