Aldosterone stimulates the non-genomic signaling pathway of the mineralocorticoid receptor in hepatic stellate cells

Introduction: The mineralocorticoid hormone aldosterone is known to regulate blood pressure and sodium retention mediated by binding of the receptor to glucocorticoid response elements and transcription of target genes. This is known as the genomic signaling pathway of the mineralocorticoid receptor (MR). However, proliferative and pro-fibrotic effects of aldosterone described in other organs have been attributed to a non-genomic signaling pathway of the MR involving protein-protein interactions with other signaling cascades, e.g. of the EGFR. This rapid pathway might be responsible for pro-fibrotic effects of a…