Bacterial DNA quantification in ascites: a novel tool to define high risk patients?
C Engelmann, S Krohn, D Prywerek, A Böhlig, A Herber, K Zeller, S Böhm, T Berg · Zeitschrift für Gastroenterologie · 2015 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Spontaneous bacterial peritonitis (SBP) represents a serious complication in patients with liver cirrhosis. Culture-based methods to detect bacteria in the ascites fluid showed limited sensitivity, and the diagnosis of SBP is therefore usually made by the surrogate of an increased total ascites leukocyte or neutrophil count. Culture-independent 16S rRNA-gene based amplification methods allowed for the detection of bacterial DNA (bactDNA) in both neutrocytic and non-neutrocytic AF but the significance of this novel tool is still debated. In the current study the impact of bactDNA quantification in asc…
