Angiogenic markers sFlt-1 and PIGF: a new diagnostic tool for patients with suspected preeclampsia

Angiogenic and antiangiogenic factors such as sFlt-1 and PlGF play a major role in the pathogenesis of preeclampsia (PE). There is a growing body of studies focusing on the prediction of PE using these markers. However, none of these studies has focused on the clinical application of these factors when PE is suspected but not clearly manifested. The aim of this study was to investigate the value of the sFlt-1/PIGF-ratio as a diagnostic tool to predict the development of PE in patients with unclear PE symptoms. Material and methods: 139 patients who did not fulfill the diagnostic criteria for PE, but showed parti…