Gal-1 silenced trophoblast tumour cells (BeWo) show decreased syncytium formation and different miRNA production compared to non-target silenced BeWo cells

Gestational pathologies such as preeclampsia, HELLP syndrome and intrauterine growth restriction are partly based on insufficient placentation. Adequate syncytium formation is an important precondition and part of placentation. Gal-1 induces cell differentiation processes on the membrane of choriocarcinoma cells BeWo, including the receptor tyrosine kinases (RTKs) REarranged during Transfection (RET), Janus Kinase 2 (JAK2) and Vascular endothelial growth factor receptor 3 (VEGFR3). The syncytium formation abilities of BeWo cells that were gal-1 silenced were analyzed using immunohistochemistry and immunofluoresc…